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Updated: Jan 7, 2026
Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
Published on: April 14, 2014
Progressive Cerebral Atrophy and Cognitive Decline Without Cerebral Lesion in Neuromyelitis Optica Spectrum Disorder:
Susumu Fujikawa1, Fumitaka Shimizu1, Masaya Honda1
1Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Ube, JPN.
None:
Neurological deficits in neuromyelitis optica spectrum disorder (NMOSD) are conventionally thought to result from acute relapses, unlike multiple sclerosis (MS), which frequently progresses without relapse due to neurodegeneration. However, we present the case of a 41-year-old male patient who showed progressive bilateral frontal lobe atrophy over nine years, although acute relapses were limited to the medulla and spinal cord. Neuropsychological testing indicated cognitive decline. This case demonstrates progressive cerebral atrophy and cognitive decline, independent of relapses in NMOSD, possibly suggesting subclinical dying-back degeneration.
