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Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
Published on: December 28, 2017
Draft genome sequences of two clinical isolates of Candida tropicalis from Iraq
Wafaa S H Al-Nasrawi1,2, Ban T Mohammed1, Adnan A Lahuf3
1Department of Biology, College of Education for Pure Science, University of Kerbala, Karbala, Iraq.
Abstract:
Candida tropicalis is an emerging human pathogen associated with oral candidiasis. In the current study, we report the draft genome sequences of two C. tropicalis isolates that were associated with multidrug resistance and outbreaks in different hospitals in Karbala province, Iraq.
Insights
Two multidrug-resistant Candida tropicalis isolates from Iraq hospitals were sequenced. This research provides genomic data on this emerging pathogen linked to oral candidiasis and hospital outbreaks.
Area of Science:
- Medical Mycology
- Genomics
- Infectious Diseases
Background:
- Candida tropicalis is an emerging fungal pathogen.
- It is frequently associated with oral candidiasis.
- Multidrug resistance in Candida species is a growing public health concern.
Purpose of the Study:
- To report the draft genome sequences of two multidrug-resistant Candida tropicalis isolates.
- To provide genomic resources for understanding Candida tropicalis outbreaks and resistance.
Main Methods:
- Whole-genome sequencing of two clinical isolates of Candida tropicalis.
- Bioinformatic analysis of the obtained draft genome sequences.
Main Results:
- The study reports the draft genome sequences of two multidrug-resistant Candida tropicalis isolates.
- These isolates were associated with hospital outbreaks in Karbala province, Iraq.
Conclusions:
- The genomic data will aid in studying the evolution and epidemiology of multidrug-resistant Candida tropicalis.
- Understanding the genetic basis of resistance is crucial for developing effective treatments against Candida tropicalis infections.
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