Green Synthesis of Silver Nanoparticles Using Hypecoum pendulum L. Extract: In Vivo Anti-Hyperglycemic and In Vitro...

Area of Science:

• Nanotechnology
• Pharmacology
• Microbiology

Background:

• Hypecoum pendulum L. (HP) extract possesses phytochemicals with therapeutic potential.
• Silver nanoparticles (AgNPs) synthesized using plant extracts offer a green approach for novel drug development.

Purpose of the Study:

• To synthesize Hypecoum pendulum L. extract-based silver nanoparticles (HP-AgNPs).
• To evaluate the in vivo anti-hyperglycemic and in vitro antimicrobial activities of HP-AgNPs.

Main Methods:

• HP-AgNPs were synthesized and characterized using UV-Vis spectroscopy, FTIR, XRD, SEM, and EDX.
• Anti-hyperglycemic activity was assessed in alloxan-induced diabetic rats over 21 days.
• Antimicrobial and antifungal activities were evaluated against various bacterial and fungal strains.

Main Results:

• Characterization confirmed the formation of face-centered cubic HP-AgNPs (36.3 nm) with silver as the primary element (49%).
• HP-AgNPs treatment significantly improved body weight, organ weight, and hemoglobin levels while reducing blood glucose, HbA1c, lipid, and liver profiles in diabetic rats.
• HP-AgNPs exhibited promising dose-dependent antibacterial and antifungal efficacy, outperforming the HP extract.

Conclusions:

• Green-synthesized HP-AgNPs are a stable and effective nanomaterial.
• HP-AgNPs demonstrate significant potential as anti-diabetic and antimicrobial agents.
• HP-AgNPs show enhanced therapeutic efficacy compared to the parent HP extract.