Related Experiment Video
Updated: Jan 8, 2026
09:17
Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma
Published on: September 13, 2022
2.7K
A practical approach for assessing high-grade diffuse gliomas and meningiomas
Yi Zhu1, Mark A Rudolf2, Kyle Conway2
1Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Human Pathology
|December 19, 2025
Summary
Surgical pathologists can assess most central nervous system (CNS) tumors using practical guidelines. This review focuses on evaluating common CNS tumor types like high-grade diffuse glioma and meningioma.
Area of Science:
- Neuropathology
- Oncology
- Genomics
Background:
- Central nervous system (CNS) tumor diagnostics are increasingly complex due to genomic markers.
- Surgical pathologists are essential for accurate CNS tumor assessment.
- Integrating new diagnostic and prognostic markers is crucial.
Purpose of the Study:
- To provide practical guidelines for surgical pathologists.
- To cover common primary malignant and benign CNS tumor entities.
- To aid in the informed assessment of CNS tumors.
Main Methods:
- Review of current literature and diagnostic standards.
- Focus on key features of high-grade diffuse glioma.
- Focus on key features of meningioma.
Main Results:
- Established guidelines for evaluating common CNS tumors.
- Highlighted the role of genomic markers in diagnostics.
- Provided a framework for assessing glioma and meningioma.
Conclusions:
- Surgical pathologists can effectively manage most CNS tumors with updated knowledge.
- Practical guidelines enhance diagnostic accuracy for common CNS entities.
- Continued evolution of CNS tumor diagnostics requires adaptable approaches.
