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Exercise During or After Intravesical Therapy for Bladder Cancer: A Randomized Feasibility Trial.

Fernanda Z Arthuso¹, Adrian S Fairey², Normand G Boulé¹

¹Faculty of Kinesiology, Sport, and Recreation, College of Health Sciences, University of Alberta, Edmonton, Alberta, Canada.

Seminars in Oncology Nursing

|December 19, 2025

Summary

This summary is machine-generated.

High-intensity interval training (HIIT) is safe and feasible for non-muscle invasive bladder cancer (NMIBC) patients undergoing intravesical therapy. This exercise intervention improved physical functioning, including walking distance and mobility.

Keywords:

Exercise Feasibility studies High-intensity interval training Intravesical administration Non-muscle invasive bladder neoplasms

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Published on: October 30, 2013

Area of Science:

Oncology
Exercise Physiology
Urology

Background:

Non-muscle invasive bladder cancer (NMIBC) affects a majority of newly diagnosed bladder cancer patients.
NMIBC and its treatments significantly impact patient quality of life and physical functioning.
Exercise is recognized for its benefits in various cancer populations, yet its role in NMIBC remains unexplored.

Purpose of the Study:

To assess the feasibility, safety, and preliminary efficacy of high-intensity interval training (HIIT) for NMIBC patients.
To evaluate HIIT's impact on physical functioning during or after intravesical therapy.

Main Methods:

The Bladder cancer and exeRcise trAining during or after intraVesical thErapy (BRAVE) trial randomized 25 NMIBC patients.
Participants were assigned to either usual care (n=12) or supervised HIIT thrice-weekly for 12 weeks (n=13).
Outcomes included exercise attendance, cardiorespiratory fitness (VO2peak), 6-minute walk distance, and timed up-and-go test.

Main Results:

High-intensity interval training (HIIT) demonstrated 100% median exercise attendance.
The HIIT group showed improvements in 6-minute walk distance (41m) and timed up-and-go (-1.0s) compared to usual care.
While VO2peak increased in the HIIT group, the difference was not statistically significant (P=.10).

Conclusions:

High-intensity interval training (HIIT) is a safe and feasible intervention for NMIBC patients undergoing intravesical therapy.
HIIT led to significant improvements in key physical functioning metrics.
Oncology nurses can recommend HIIT to NMIBC patients to enhance physical well-being.