Related Experiment Video
Updated: Jan 8, 2026

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device
Published on: May 2, 2025
[Pediatric soft tissue tumors in the 2024 WHO pediatric classification: Challenges and new developments]
Ludovic Merck1, Charles Lepine2, Louise Galmiche-Rolland3
1Université de Bordeaux, Talence, France; Institut Bergonié, département de pathologie, 229 cours de l'Argonne, 33000, Bordeaux, France.
Abstract:
In 2024, the WHO published for the first time an international classification dedicated to all pediatric tumors, marking a major milestone for the pediatric pathology community with the release of the pediatric "Blue Book." This review will focus on soft tissue connective tumors. Unsurprisingly, their classification follows the structure of the 2020 WHO classification for connective tissue tumors, organized according to histogenetic categories (adipocytic tumors, fibroblastic/myofibroblastic tumors, etc.). For each entity, we will highlight the essential elements for pathologists, emphasizing recent advances, including those not yet included in the WHO classification. Indeed, its international and consensus-based editorial process does not always allow for the integration of the most recent discoveries.

