Related Experiment Video
Updated: Jan 8, 2026
Ultrasonographic Evaluation of Breast Cancer-related Lymphedema
Published on: January 12, 2017
A Delphi consensus for a nurse-led personalized exercise intervention in breast cancer patients during chemotherapy
Huijie Wei1,2, Wubin He3
1First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.
Background:
Chemotherapy-induced peripheral neuropathy (CIPN) and cancer-related fatigue (CRF) are prevalent and debilitating side effects in breast cancer patients, adversely affecting treatment adherence and quality of life. Although exercise is beneficial, a standardized, practical protocol for integrating nurse-led exercise interventions into clinical pathways during chemotherapy is not yet established.
Methods:
A three-round modified Delphi study was conducted between February and May 2025 among a multidisciplinary panel of 22 experts, including oncology nurses, breast oncologists, rehabilitation therapists, and patient advocates. Anonymized, structured questionnaires were administered electronically. Consensus was predefined as a mean score ≥ 4.0 (on a 5-point Likert scale), agreement by ≥ 75% of respondents, and standard deviation ≤ 1.0. Kendall's coefficient of concordance (W) was used to assess stability of rankings across rounds.
Results:
High response rates were maintained across all rounds (100%, 95%, 100%). A strong consensus was achieved regarding 42 discrete items. Key agreements included: (1) initiating assessment and exercise prescription at the first chemotherapy cycle; (2) implementing a multi-component regimen combining aerobic, resistance, and balance training; (3) clearly defining nurses' roles in assessment, education, and monitoring; (4) personalizing exercise intensity based on daily patient-reported symptoms (e.g., fatigue); and (5) integrating digital tools for adherence support and documentation.
Conclusions:
This study establishes a robust expert consensus on a structured, nurse-led, personalized exercise intervention package for integration into the clinical pathway of breast cancer patients undergoing chemotherapy. The framework offers practical guidance for mitigating treatment-related side effects and improving patient outcomes. Future research should focus on evaluating its feasibility and effectiveness in diverse clinical settings.
Trial Registration:
Not applicable.
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