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Cannabidiol-based lipid nanocarriers with analgesic activity
Arissa de Oliveira Sato1, João Pedro Tánnus Goulart1, Tamiris Sabrina Rodrigues1
1Institute of Biotechnology, Federal University of Uberlândia, Uberlândia, Brazil.
Scientific Reports
|December 19, 2025
Summary
This study developed a stable nanostructured lipid carrier (NLC) formulation encapsulating cannabidiol (CBD) for pain management. The NLC/CBD system demonstrated no toxicity and effective pain relief in biological models.
Area of Science:
- Pharmacology
- Nanotechnology
- Biomaterials
Background:
- Pain management faces challenges with current treatments like opioids due to toxicity and limited efficacy.
- Cannabidiol (CBD) shows promise for pain relief, but effective delivery systems are needed.
- Nanoencapsulation using nanostructured lipid carriers (NLC) can enhance drug delivery and stability.
Purpose of the Study:
- To develop and characterize a stable nanostructured lipid carrier (NLC) formulation loaded with cannabidiol (CBD).
- To evaluate the in vivo toxicity and analgesic efficacy of the NLC/CBD formulation.
- To explore NLC/CBD as a potential safe and effective nanosystem for pain management.
Main Methods:
- CBD oil was encapsulated within nanostructured lipid carriers (NLC) to create the NLC/CBD formulation.
- Formulation stability was assessed over 365 days at 25°C.
- In vivo toxicity was evaluated using chicken embryos, and analgesic effects were tested in Drosophila melanogaster.
Main Results:
- The NLC/CBD formulation exhibited excellent stability, remaining stable for 365 days at 25°C.
- No toxicity was observed in chicken embryos at concentrations up to 2.87 mg/mL.
- Significant analgesic effects of NLC/CBD (1.0 mg/mL) were confirmed in Drosophila melanogaster.
Conclusions:
- The developed NLC/CBD formulation is a stable, biocompatible, and non-toxic nanosystem.
- NLC encapsulation enhances the potential of CBD for effective pain management.
- This herbal-based NLC/CBD system offers a promising, cost-effective therapeutic strategy for pain relief.
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