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Cannabis-Based Nanolipid Formulations for Pain Management
Ana Clara Santiago Bastos1, Arissa De Oliveira Sato2, Luana Carvalho de Oliveira1
1Department of Pharmacy, Faculty of Pharmacy, Federal University of Rio Grande do Norte, Natal 59012-570, RN, Brazil.
Pharmaceutics
|July 28, 2026
Summary
Nanoencapsulation enhances the stability and bioavailability of cannabinoids like CBD and THC for pain relief. Further research is needed to standardize methods for clinical application of these cannabis-based therapies.
Area of Science:
- Pharmacology
- Nanotechnology
- Pain Management
Background:
- Medicinal cannabis, particularly cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC), shows therapeutic potential for pain.
- Cannabinoids face challenges with stability and bioavailability, limiting their clinical use.
Purpose of the Study:
- To review and analyze evidence on the antinociceptive effects of nanoencapsulated cannabinoids versus free compounds.
- To identify research gaps and limitations in nanostructured cannabinoid-based systems for pain management.
Main Methods:
- Systematic review and analysis of published literature on nanoencapsulated cannabinoids for pain.
- Examination of various pharmaceutical formulations and administration routes in preclinical pain models.
Main Results:
- Cannabinoids demonstrate promising analgesic effects, with nanoencapsulation potentially improving stability and bioavailability.
- Limited research exists on nanostructured cannabinoid systems, predominantly preclinical, with noted data quality issues.
Conclusions:
- Nanoencapsulation is a promising strategy to enhance cannabinoid therapy for pain, overcoming intrinsic limitations.
- Standardized methodologies are crucial for translating preclinical findings into safe, effective clinical cannabinoid-based treatments.
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