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Updated: May 13, 2026

Fully Autonomous Characterization and Data Collection from Crystals of Biological Macromolecules
Published on: March 22, 2019
A new macromolecular crystallography endstation at NanoTerasu for accelerating structural biology and drug discovery
Yusuke Yamada1, Keisuke Sakurai1, Akiya Fukuda2
1International Center for Synchrotron Radiation Innovation Smart, Tohoku University, 468-1 Aramaki Aza-Aoba, Aoba-ku, Sendai, Miyagi 980-8572, Japan.
Abstract:
Since the fiscal year 2022, `Support Program for Life Science and Drug Discovery Research (BINDS Phase II)', funded by the Japan Agency for Medical Research and Development (AMED), has been supporting structural analysis research in Japan, promoting the further development of various advanced structural analysis technologies. The BINDS project aims to offer more timely and cutting-edge support by establishing a new macromolecular crystallography endstation (MX-ES) at NanoTerasu, Japan's first fourth-generation synchrotron-radiation facility. MX-ES has been equipped with microbeam focusing optics and a state-of-the-art measurement system for fully automated, high-throughput data collection from cooled crystals. Commissioning and initial experiments have been completed. User operations are expected to begin in the second half of the fiscal year 2025.

