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Dissecting Mechanoenzymatic Properties of Processive Myosins with Ultrafast Force-Clamp Spectroscopy
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Myosin Modulator Aficamten Inhibits Force by Altering Myosin's Biochemical Activity Without Changing Thick Filament

Saffie Mohran1, Kristina B Kooiker1, Ateeqa Naim2

  • 1Division of Cardiology, Medicine, University of Washington, Seattle Washington, USA; Center of Translational Muscle Research, University of Washington, Seattle, Washington, USA; Center for Cardiovascular Biology, University of Washington, Seattle, Washington, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington, USA.

JACC. Basic to Translational Science
|December 20, 2025
PubMed

Keywords:
cardiac myosin inhibitorsdarcomereengineered heart tissueshypertrophic cardiomyopathymuscle x-ray diffractionmyosin ATPase activity

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