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Updated: Jan 8, 2026

Murine Model of Epicutaneously-Induced Immunomodulation
Published on: June 24, 2025
Mass immunization without public consent
Zhaohui Su1, Yudu Liu2, Ruijie Zhang3
1School of Public Health, Institute for Human Rights, Southeast University, Nanjing, China; Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, China.
Abstract:
The development of needle-free, nonintrusive vaccine technologies promises to transform public health campaigns by improving acceptability and ease of administration. However, this convenience introduces a critical ethical vulnerability: the potential for large-scale deployment without individual knowledge or consent, leading to nonconsensual immunization. This article analyzes this risk through the lens of established bioethical principles-autonomy, nonmaleficence, beneficence, and justice-and historical precedents, examining how the ease of use of nonintrusive formats, combined with precedents of rapidly enforced mandates, could undermine informed consent. To address this challenge, we propose a proactive governance framework based on three pillars: strengthening international ethical guidelines, enacting national laws against covert mass medication, and exploring technological monitoring of public infrastructure. This approach aims not to impede public health action, but to reinforce it by upholding individual autonomy and maintaining essential public trust.
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