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Updated: Jan 8, 2026

In utero Measurement of Heart Rate in Mouse by Noninvasive M-mode Echocardiography
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The expanding role of Furin in human Disease: A comprehensive review
Xinyang Li1, Chong Liu1, Haidi Hu1
1Department of General and Vascular Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, China.
Abstract:
Furin is a calcium-dependent serine endoprotease that activates multiple substrates by cleaving at polybasic motifs, playing a pivotal role in human physiology and pathology. This review summarizes the latest research progress regarding Furin's extensive involvement in infectious diseases, tumor diseases, cardiovascular diseases, neurodegenerative diseases, metabolic diseases, and autoimmune diseases. This review offers an in-depth analysis of Furin's dual functions, which include promoting viral entry into host cells, driving oncogenesis via growth factors, metalloproteinases, and the Notch signaling pathway, and maintaining metabolic homeostasis and immune tolerance. Key pathophysiological mechanisms involve the dysfunction of Furin substrate activation in atherosclerosis, hypertension, Alzheimer's disease, diabetes, and other disorders. The review also highlights the potential value of Furin as a diagnostic and prognostic biomarker and therapeutic target, while pointing out the challenges encountered in developing its inhibitors.
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