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Decoding SDCBP's role in tumor progression and immune cells infiltration: from databases to macrophage validation
Chanyuan Zhao1, Chenli Zhang1,2, Xiaoyu Zhang1
1Institute of Pathology, School of Basic Medical Sciences, Lanzhou University, Donggang West Road 199, Lanzhou, 730000, Gansu, China.
Discover Oncology
|December 21, 2025
Summary
Syndecan binding protein (SDCBP) impacts tumor progression and immune cell infiltration, particularly macrophages. Targeting SDCBP may offer new strategies for cancer treatment and immunotherapy.
Area of Science:
- Oncology
- Immunology
- Molecular Biology
Background:
- Tumor biomarkers are crucial for cancer prognosis and therapy.
- Immune cells in the tumor microenvironment (TME) have complex roles in cancer.
- Syndecan binding protein (SDCBP) is implicated in metastasis, but its role in TME immune cell infiltration is unknown.
Purpose of the Study:
- To investigate the pan-cancer expression and prognostic value of SDCBP.
- To explore the effect of SDCBP on immune cell infiltration in the TME, with a focus on macrophages.
- To elucidate the functional role of SDCBP in macrophages.
Main Methods:
- Comprehensive analysis of multiple public databases for SDCBP expression and patient prognosis.
- Gene Set Enrichment Analysis (GSEA) to identify SDCBP-associated pathways.
- Experimental validation using THP-1-derived macrophages to assess SDCBP's effect on chemotaxis, polarization, and phagocytosis.
Main Results:
- SDCBP is differentially expressed across various tumor tissues and cells.
- Elevated SDCBP expression correlates with advanced cancer, poor prognosis, and treatment resistance.
- SDCBP is highly expressed in macrophages and influences their chemotaxis but not polarization or phagocytosis.
Conclusions:
- SDCBP plays a role in tumor progression and macrophage infiltration within the TME.
- SDCBP represents a potential therapeutic target and biomarker for cancer, especially in combination with immunotherapy.
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