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Updated: Jan 8, 2026

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

Published on: October 6, 2022

Searching for a HIV-1 Cure.

Chen Zhang¹, Bharat N Chaudhary¹, Mohammad Uzair Ali¹

¹Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA 68198-5880.

|December 22, 2025

Summary

This summary is machine-generated.

Researchers are exploring novel therapies like gene editing to cure HIV-1. Current methods face challenges in durability and accessibility, but gene editing shows promise for disrupting viral DNA and achieving a functional cure.

Keywords:

CCR5 CD4 CRISPR CRISPR-Cas9 CXCR4 Combination antiretroviral therapy Gene Delivery HIV-1 replication HIV-1 suppression Viral resistance

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Last Updated: Jan 8, 2026

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Area of Science:

Virology
Immunology
Gene Therapy

Background:

Significant advancements in HIV-1 cure strategies include stem cell transplantation, broadly neutralizing antibodies, ultra-long-acting antiretrovirals, therapeutic vaccines, and cell/gene therapies.
Despite progress, current approaches lack durability and face challenges in accessibility, delivery, off-target effects, and practicality for widespread clinical use.

Purpose of the Study:

To review current and emerging strategies for achieving a durable cure for human immunodeficiency virus type 1 (HIV-1).
To examine the scientific, clinical, and ethical considerations of various therapeutic modalities, with a focus on gene-editing technologies.

Main Methods:

Review of existing literature on HIV-1 cure strategies, including combinatorial therapies.
Focus on gene-editing technologies, direct viral excision, and co-receptor editing for targeting latent reservoirs and host viral receptors.

Main Results:

Current therapeutic approaches, including combinations of antiretrovirals, antibodies, and latency-reversing agents, aim for durable viral suppression but not complete eradication.
Gene-editing technologies demonstrate potential in disrupting proviral DNA and enabling targeted therapies against latent HIV-1 reservoirs.

Conclusions:

Achieving a durable HIV-1 cure remains challenging due to issues of durability, accessibility, and practicality.
Gene editing, particularly direct viral excision and co-receptor editing, presents a promising strategy for a functional HIV-1 cure by targeting latent reservoirs and host factors.