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Considerations in Eyelid Reconstruction in Treacher Collins Syndrome: A Scoping Review
John Vandevender1, Royce B Park2, Akriti Choudhary1
1University of Illinois at Chicago College of Medicine, Chicago, IL, USA.
FACE (Thousand Oaks, Calif.)
|December 22, 2025
Summary
Treacher Collins syndrome (TCS) eyelid repair outcomes were reviewed. Coloboma repairs showed the highest success rate (92%), though also the highest revision rate, highlighting the need for tailored surgical management.
Area of Science:
- Ophthalmology
- Plastic Surgery
- Genetics
Background:
- Treacher Collins syndrome (TCS) is a rare congenital disorder causing significant craniofacial and eyelid deformities.
- Existing literature lacks a comprehensive summary of surgical outcomes for TCS-related eyelid abnormalities.
Purpose of the Study:
- To systematically review and summarize surgical outcomes for eyelid repair in patients with Treacher Collins syndrome.
- To identify the most effective surgical approaches for various TCS eyelid defects.
Main Methods:
- A PRISMA-guided literature review was conducted, analyzing 24 articles involving 144 patients and 212 procedures.
- Successful outcomes were defined by author-reported improvement or satisfaction.
Main Results:
- The most common eyelid defects in TCS are pseudocolobomas (54%), lateral canthal dystopia (38%), and true colobomas (8%).
- Coloboma repair achieved the highest success rate (92%), followed by pseudocoloboma (80%) and lateral canthal dystopia repair (79%).
- Coloboma repair had the highest revision rate (13%), while pseudocoloboma repair had a 2% revision rate.
Conclusions:
- TCS eyelid abnormalities necessitate individualized surgical plans considering defect type and prior craniofacial reconstruction.
- Tailored surgical management is crucial for optimizing functional and aesthetic outcomes in TCS patients.
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