New-Onset Atrial Fibrillation Potentially Associated With Tirzepatide: A Case Report

Akhtar Purvez1,2, Mohd Mirza3, Mudhasir Bashir4

  • 1Clinical Research, Momentum Medical Research, Charlottesville, USA.

Cureus
|December 22, 2025
PubMed
Summary

Tirzepatide, a GIP/GLP-1 receptor agonist, may rarely cause atrial fibrillation (AF) in patients without prior heart issues. Discontinuation resolved the AF, emphasizing monitoring for cardiac events with incretin therapies.

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