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Toward precision longevity: aging interventions in the single-cell atlas era.
Jason B Chen1,2, Miranda C Wang1,2, Shangyu Gong1,2
1Huffington Center on Aging, Baylor College of Medicine, Houston, TX, United States.
Frontiers in Aging
|December 22, 2025
Summary
Researchers reviewed interventions for healthy aging, including genetics and diet, in model organisms. Integrating single-cell data can improve targeted longevity strategies for better healthspan.
Area of Science:
- Gerontology and aging research.
- Biomedical science and molecular biology.
Background:
- Healthy aging and extending healthspan are key goals in biomedical research.
- Current longevity interventions are studied in model organisms like C. elegans, Drosophila, and Mus musculus.
Purpose of the Study:
- To review current longevity interventions and their limitations.
- To highlight the role of single-cell aging atlases in understanding aging.
- To propose future precision aging strategies.
Main Methods:
- Review of existing literature on longevity interventions.
- Analysis of studies in model organisms (C. elegans, Drosophila, Mus musculus).
- Emphasis on single-cell aging atlas technologies.
Main Results:
- Longevity interventions show promise but have limitations, including tissue variability.
- Single-cell technologies reveal cell-type-specific aging patterns.
- Aging varies significantly across different cell types and tissues.
Conclusions:
- Future longevity interventions require precise targeting at the cellular level.
- Integrating single-cell data is crucial for enhancing intervention efficacy and specificity.
- Precision medicine approaches can optimize healthy aging strategies.
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