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Updated: Jan 8, 2026

Modeling the Functional Network for Spatial Navigation in the Human Brain
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Poorer physical function is associated with elevated spatial entropy in the aging brain network landscape.

Clayton C McIntyre, Shannon M O'Donnell, Robert G Lyday

    Biorxiv : the Preprint Server for Biology
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    Summary
    This summary is machine-generated.

    Aging increases brain entropy, particularly in sensorimotor areas, linked to poorer physical function. Maintaining a healthy weight may help reduce this brain disorder and preserve mobility in older adults.

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    Area of Science:

    • Neuroscience
    • Aging Research
    • Biophysics

    Background:

    • The aging process is associated with a decline in the brain's ability to maintain internal order.
    • Healthy brains exhibit spatially consistent, functionally segregated network communities forming a functional landscape.
    • Disruptions in this brain network landscape are linked to cognitive and physical function decline.

    Purpose of the Study:

    • To investigate the relationship between aging, brain network spatial disorder (entropy), and physical function.
    • To identify specific brain regions where entropy increases with age and correlates with physical decline.

    Main Methods:

    • Utilized a modified Shannon entropy measure to quantify spatial disorder in brain network landscapes.
    • Compared entropy levels in older adults with varying mobility to younger adults.
    • Correlated brain entropy with physical function metrics and body mass index.

    Main Results:

    • Older adults exhibited significantly higher brain entropy than younger adults in key regions like the sensorimotor cortex, basal ganglia, hippocampus, thalamus, and occipital lobe.
    • Increased entropy in these regions was associated with diminished physical function and higher body mass index.
    • Spatial entropy in brain network landscapes may serve as a biomarker for age-related physical function decline.

    Conclusions:

    • Aging leads to increased spatial entropy in specific brain network landscapes, particularly in regions crucial for motor control and sensory processing.
    • Higher brain entropy in older adults is linked to poorer physical function and higher BMI.
    • Lifestyle modifications, such as weight management, may help mitigate age-related increases in brain entropy and preserve physical function.