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Poorer Physical Function Is Associated With Elevated Spatial Entropy in the Aging Brain Network Landscape.

Clayton C McIntyre1, Shannon M O'Donnell1, Robert G Lyday2

  • 1Neuroscience Graduate Program, Wake Forest Graduate School of Arts and Sciences, Winston-Salem, North Carolina, USA.

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Summary
This summary is machine-generated.

Aging brains show increased spatial disorder, particularly in sensorimotor areas. This brain network entropy correlates with reduced physical function and higher body mass index in older adults.

Keywords:
agingbrain networksentropyobesityphysical function

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Area of Science:

  • Neuroscience
  • Aging Research
  • Systems Biology

Background:

  • The aging process is characterized by a decline in the ability to maintain internal order.
  • In healthy brains, functional network communities exhibit spatial consistency, forming a functional landscape associated with specific cognitive and physical functions.

Purpose of the Study:

  • To assess spatial disorder in brain network landscapes of older adults using Shannon entropy.
  • To investigate the relationship between brain entropy, physical function, and body mass index in aging.

Main Methods:

  • Utilized a spatial form of Shannon entropy to quantify disorder in brain network landscapes.
  • Compared entropy levels between younger and older adults across various brain regions.
  • Correlated regional brain entropy with physical function and body mass index in older adults.

Main Results:

  • Older adults exhibited significantly higher spatial entropy compared to younger adults in the sensorimotor cortex, basal ganglia, hippocampus, thalamus, and occipital lobe.
  • Increased entropy in these regions was associated with poorer physical function and higher body mass index.

Conclusions:

  • Spatial entropy in brain network landscapes may serve as a biomarker for age-related decline in physical function.
  • Modifiable factors like weight management could potentially mitigate age-related increases in brain entropy, aiding in physical function preservation.