Efficient synthesis of benzo(hetero)aryl-5-yl(2-hydroxyphenyl)methanones via mechanochemical benzannulation
Qiuling Xu1, Qinghong Cui1, Junliang Wang1
1Scientific Research and Experimental Center, Yunnan University of Chinese Medicine, Kunming, Yunnan, 650500, P. R. China. wangjunliangedu@163.com.
Abstract:
A new mechanochemical approach to novel benzo(hetero)aryl-5-yl(2-hydroxyphenyl)methanones is disclosed. The advantages of this approach include its avoidance of potentially harmful organic solvents, relatively short reaction times, and relatively simple operational handling. Upon sp3 C-H activation, unprecedented benzannulations of 2-methylbenzaldehyde and 2-methylindole-3-carbaldehyde with 3-formylchromones were successfully achieved, accompanied by significantly reduced E-factors. Products from our reactions are very useful and have the potential to be readily transformed into sophisticated multicyclic molecules and chemical auxiliaries.
More Related Videos
Related Concept Videos
Benzene to Phenol via Cumene: Hock Process
Diazonium Group Substitution with Halogens and Cyanide: Sandmeyer and Schiemann Reactions
Nucleophilic Aromatic Substitution: Elimination–Addition
Electrophilic Aromatic Substitution: Nitration of Benzene
Nucleophilic Aromatic Substitution of Aryldiazonium Salts: Aromatic SN1
In the Sandmeyer reaction, for example, the diazonio group is replaced by a chloro, bromo,...
Reactions at the Benzylic Position: Halogenation


