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Strong PSMA Expression by a Pituitary Macroadenoma on PSMA PET/CT
Ava Mohseny1, Mudassir Mumtaz, Busra Cangut
1Department of Diagnostic, Molecular, and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY.
Clinical Nuclear Medicine
|December 22, 2025
Summary
An 81-year-old man
Area of Science:
- Nuclear Medicine
- Oncology
- Endocrinology
Background:
- Elevated Prostate-Specific Antigen (PSA) prompted a prostate biopsy.
- Biopsy revealed Gleason grade 7 (3+4) prostate cancer.
Purpose of the Study:
- To report a case of false-positive imaging in prostate cancer staging.
- To highlight a potential imaging pitfall in PSMA PET/CT.
Main Methods:
- 18F-DCFPyL PSMA PET/CT for staging.
- Pituitary MRI for confirmation.
Main Results:
- PSMA PET/CT showed focal uptake in the pituitary region.
- Pituitary MRI confirmed a suprasellar macroadenoma.
- The macroadenoma exhibited strong PSMA expression.
Conclusions:
- Pituitary macroadenoma can exhibit strong PSMA expression.
- This finding represents a potential false positive in PSMA PET/CT imaging.
- Recognition of this pitfall is crucial for accurate staging.
