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Rectal Methamphetamine Use, a Likely Cause of Sigmoid Colon Perforation: A Case Report
Journal of Addiction Medicine
|December 23, 2025
Summary
This case report details a rare instance of sigmoid colon perforation linked to chronic rectal methamphetamine use. This highlights a previously undocumented gastrointestinal complication of methamphetamine abuse.
Area of Science:
- Gastroenterology
- Toxicology
- Colorectal Surgery
Background:
- Methamphetamine (MA) is a potent central nervous system stimulant.
- MA use is associated with significant behavioral and cardiovascular complications.
- Gastrointestinal (GI) complications of MA use are underreported, with no documented cases of colonic perforation.
Purpose of the Study:
- To report a novel case of sigmoid colon perforation.
- To highlight a previously unrecognized gastrointestinal complication of chronic methamphetamine administration.
Main Methods:
- Case report of a patient presenting with symptoms of colonic perforation.
- Review of existing literature on methamphetamine-induced complications.
Main Results:
- The patient experienced perforation of the sigmoid colon.
- This is the first reported case of colonic perforation attributed to chronic rectal methamphetamine administration.
- Literature search revealed no prior instances of this complication.
Conclusions:
- Chronic rectal methamphetamine administration can lead to severe gastrointestinal complications, including colonic perforation.
- This case expands the known spectrum of adverse effects associated with methamphetamine abuse.
- Further research is warranted to understand the mechanisms and prevalence of GI complications from methamphetamine use.
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