DNA Technology-Based Cell Membrane Engineering for Biomedical Applications

The cell membrane serves as the primary interface between cells and their extracellular microenvironments, playing a crucial role in target recognition, signal transmission, and material transport. By engineering of the cell membrane, it is possible to bestow cells with various artificial functions. DNA technology represents excellent programmability, functional diversity, and biocompatibility, providing unique advantages in the field of cell membrane engineering. DNA technology facilitates the functionalization of cells, endowing them with capabilities such as signal output, target recognition, and chemical catalysis, which broadens the potential applications of cells across diverse fields. In this review, we summarize the recent advancements in DNA technology-based cell membrane engineering. It focuses on anchoring methods and their practical applications in biomedical diagnosis, therapy, and biomimetic simulation. Finally, we address the challenges and future prospects associated with the integration of DNA technology in cell membrane engineering.