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DNA Technology-Based Cell Membrane Engineering for Biomedical Applications.

Jie Deng1, Runchi Zhang1, Haipeng Qi1,2

  • 1Department of Clinical Laboratory Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, P. R. China.

ACS Applied Bio Materials
|December 23, 2025
PubMed
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This summary is machine-generated.

DNA technology enhances cell membranes with artificial functions for applications in medicine and biomimetics. This review covers DNA-based cell membrane engineering methods and their uses.

Area of Science:

  • Biotechnology
  • Molecular Biology
  • Cell Biology

Background:

  • The cell membrane is vital for cell-environment interactions, including recognition, signaling, and transport.
  • Engineering cell membranes can impart novel functionalities to cells.
  • DNA technology offers programmability and biocompatibility for cell membrane engineering.

Purpose of the Study:

  • To review advancements in DNA technology for cell membrane engineering.
  • To highlight DNA-based methods for functionalizing cell membranes.
  • To discuss applications in biomedical diagnosis, therapy, and biomimetic simulation.

Main Methods:

  • Review of recent literature on DNA technology in cell membrane engineering.
  • Focus on DNA anchoring strategies for cell surface modification.
Keywords:
DNA self-assemblycellcell membranecell surface engineeringfunctionalization

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  • Exploration of diverse applications enabled by DNA-functionalized cells.

    • Main Results:

    • DNA technology enables precise control over cell membrane functions.
    • Various anchoring methods facilitate the integration of DNA constructs onto cell surfaces.
    • Engineered cells show potential in diagnostics, therapeutics, and biomimetic systems.

    Conclusions:

    • DNA-based cell membrane engineering is a rapidly advancing field.
    • Significant potential exists for applications in biomedicine and beyond.
    • Challenges remain in optimizing methods and exploring future prospects.