Related Experiment Video
Updated: Jan 8, 2026

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease
Published on: May 9, 2022
The Effect of Periodontal Therapy on Renal Function and Diabetes Control in Patients With Chronic Kidney Disease. A
Spyridon K Kouris1, Yiorgos A Bobetsis1, Sophia Lionaki2
1Department of Dentistry, Department of Periodontics, National and Kapodistrian University of Athens, School of Health Sciences, Athens, Greece.
Aim:
To investigate the effect of non-surgical periodontal therapy (NSPT) on renal function and glycaemic control in chronic kidney disease (CKD) patients over a 6-month observation period, through a randomised clinical trial (RCT).
Materials And Methods:
A total of 53 patients participated: 27 in the intervention group (IG) and 26 in the control group (CG). Outcomes included estimated glomerular filtration rate (eGFR, calculated using serum creatinine or both serum creatinine and cystatin-C), urine albumin to urine creatinine ratio (uACR) and serum high-sensitivity C-reactive protein (hsCRP) levels. Glycaemic control was assessed using HbA1c levels in patients with diabetes mellitus (DM).
Results:
Intra-group ΔeGFR levels were 10.26 mL/min/1.73 m2 (p < 0.001) and 11.17 mL/min/1.73 m2 (p < 0.001), depending on the equation used, favouring IG. hsCRP levels were reduced by 84% (p < 0.001) compared to CG; ΔHbA1c decreased by 0.54% (p = 0.003) at 6 months. uACR was lower but only marginally (not statistically significant) in IG.
Conclusion:
Despite its limitations, this RCT shows that NSPT enhances renal function-increasing eGFR and decreasing hsCRP-and improves glycaemic control in CKD patients with DM.
Related Concept Videos
Chronic Kidney Disease III: Interprofessional Care
Chronic Kidney Disease I: Introduction
Diabetes: Management and Pharmacotherapy
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
Chronic Kidney Disease IV: Nursing Management
Factors Affecting Renal Clearance: Renal Impairment
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...

