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Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology
Published on: May 31, 2024
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The association between intravitreal injections and glaucoma: an update
Chi Phan1, Mary Qiu2, Alice Yang Zhang1
1Department of Ophthalmology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Current Opinion in Ophthalmology
|December 23, 2025
Summary
Intravitreal antivascular endothelial growth factor (VEGF) injections can cause temporary or lasting high intraocular pressure (IOP), risking optic nerve damage. Individualized management and prophylactic measures are key to mitigating these complications in retinal disease patients.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Vascular Biology
Background:
- Intravitreal anti-VEGF injections are standard for retinal diseases.
- Concerns exist regarding intraocular pressure (IOP)-related complications.
- Understanding IOP dynamics is crucial for patient safety.
Purpose of the Study:
- To review current evidence on IOP changes after anti-VEGF injections.
- To examine transient and sustained IOP elevations.
- To discuss structural/vascular effects and management strategies.
Main Methods:
- Literature review of recent studies on anti-VEGF injections and IOP.
- Analysis of factors influencing IOP spikes and sustained elevation.
- Evaluation of clinical outcomes and management approaches.
Main Results:
- Acute IOP spikes are common, usually resolving within an hour, but delayed in glaucoma/OHT.
- Spike magnitude varies with patient and technical factors.
- Sustained elevation is linked to specific agents and cumulative injections, potentially causing RNFL thinning and requiring glaucoma surgery.
Conclusions:
- Standard protocols are insufficient; individualized management is necessary.
- Prophylactic strategies, careful agent selection, and multidisciplinary care can reduce IOP-related risks.
- Mitigating complications requires tailored approaches for susceptible patients.
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