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Updated: Jan 8, 2026

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
Published on: September 27, 2024
Correlation Between the Levels of Fasting and Postprandial ApoB48 with Metabolic Syndrome: A Cross-Sectional Study
Yale Tang1,2, Shaojing Zeng2, Xiaoyu Hou2
1Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, 050017, People's Republic of China.
Purpose:
This study aims to determine apolipoprotein B-48 (ApoB48) levels before and after a high-fat diet in individuals with metabolic syndrome (MetS), and to explore its relationship with MetS. It provides new risk markers for exploring the mechanism of MetS and offers important theoretical basis and candidate targets for subsequent research.
Patients And Methods:
A total of 192 adult Chinese volunteers were enrolled in this cross-sectional study. Participants were divided into control and MetS groups according to the NCEP ATP III diagnostic criteria for MetS. All participants underwent oral fat tolerance testing (OFTT). Serum concentrations of fasting and postprandial ApoB48 were measured, and their relationships with each MetS component were analyzed.
Results:
Among 192 participants, 81 were diagnosed with MetS. Both fasting and postprandial ApoB48 concentrations were higher in the MetS group than in the control group (P < 0.05). The incidence of MetS increased with rising ApoB48 levels. In both groups, ApoB48 concentrations initially increased and then decreased after OFTT, peaking at 4 h postprandially, with higher peak values observed in the MetS group. Fasting and 2-h postprandial ApoB48 levels had the strongest correlations with MetS.
Conclusion:
Higher ApoB48 levels before and after OFTT were positively correlated with an increased risk of MetS and were higher than those in the healthy population. Fasting ApoB48 and 2-h postprandial ApoB48 levels after a high-fat meal may be potential markers of MetS.
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