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Hormonal Modulation of Fat Mass Induced Insulin Resistance

Humam Emad Rajha1, Ahmed Arabi1, Dima Nasrallah1

  • 1Department of Population Medicine, College of Medicine, QU Health, Qatar University, Doha, Qatar.

Metabolic Syndrome and Related Disorders
|December 23, 2025
PubMed
Summary

Body mass index (BMI) impacts insulin sensitivity (HOMA-S) and pancreatic function (HOMA-B). Hormones like leptin and GIP are stronger predictors of insulin sensitivity than BMI alone in adults with obesity.

Keywords:
BMIGIPHOMAdose responseinsulin sensitivityleptinpancreatic β-cell

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