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Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

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Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

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Enzyme-Responsive Polymeric Materials with Anticancer and Antibacterial Activities.

Desoshree Ghosh¹, Sagar Bag¹, Priyadarsi De¹

¹Polymer Research Centre and Centre for Advanced Functional Materials, Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Nadia, Mohanpur 741246, West Bengal, India.

Biomacromolecules

|December 23, 2025

Summary

Enzyme-responsive polymers (ERPs) offer advanced therapeutic solutions for cancer and bacterial infections. This review explores recent ERP advancements and highlights novel enzymes for future biomedical applications.

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Area of Science:

Biomaterials Science
Polymer Chemistry
Biomedical Engineering

Background:

Enzymes catalyze biochemical reactions with high selectivity and efficiency.
Enzyme-responsive polymers (ERPs) leverage these enzymatic properties for therapeutic applications.
Polymeric materials offer biocompatibility and tunable properties for drug delivery systems.

Purpose of the Study:

To review recent advancements (2014-present) in enzyme-responsive polymers for anticancer and antibacterial therapies.
To identify underexplored enzymes with potential for novel ERP design.
To guide the predictable application of ERPs in addressing biomedical challenges.

Main Methods:

Literature review of recent scientific publications (2014-present).
Analysis of enzyme-responsive polymer applications in oncology and infectious diseases.
Identification and discussion of emerging enzymes for future ERP development.

Main Results:

Significant progress has been made in developing ERPs for targeted cancer and antibacterial treatments.
Several promising enzymes, previously underexplored, show potential for innovative ERP design.
Recent advancements demonstrate the efficacy of ERPs in enhancing therapeutic outcomes.

Conclusions:

Enzyme-responsive polymers represent a powerful platform for advanced therapeutic strategies.
Further exploration of novel enzymes can unlock new possibilities in ERP-based biomedical applications.
Predictable design of ERPs is crucial for overcoming critical healthcare challenges.