Increased 18 F-AV1451 Retention in Soft Tissue of Patients With Progressive Supranuclear Palsy

Area of Science:

• Neurology
• Radiology
• Molecular Imaging

Background:

• Progressive supranuclear palsy (PSP) is a neurodegenerative disorder.
• Tau pathology is implicated in PSP pathogenesis.
• Novel imaging tracers are needed for PSP assessment.

Purpose of the Study:

• To report 18F-AV1451 PET/MRI findings in a patient with PSP.
• To explore the potential of 18F-AV1451 for assessing systemic tau pathology in PSP.
• To evaluate the correlation between tracer uptake and disease severity.

Main Methods:

• Positron Emission Tomography/Magnetic Resonance Imaging (PET/MRI) using the 18F-AV1451 tracer.
• Case study of a 56-year-old male patient diagnosed with PSP.

Main Results:

• Multifocal 18F-AV1451 uptake observed in both intracranial and extracranial regions.
• Increased tracer retention noted in bilateral basal ganglia and scalp soft tissue.
• Findings suggest systemic tau deposition beyond the central nervous system.

Conclusions:

• 18F-AV1451 PET/MRI may reveal systemic tau pathology in PSP.
• Extracranial tracer uptake warrants further investigation in PSP.
• This imaging approach could potentially aid in assessing PSP disease severity.