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Re-Visible Dual-Domain Self-Supervised Deep Unfolding Network for MRI Reconstruction
IEEE Journal of Biomedical and Health Informatics
|December 23, 2025
Summary
This study introduces a new self-supervised deep learning network for faster Magnetic Resonance Imaging (MRI) acquisition using under-sampled data. The method improves reconstruction quality by mitigating input distribution shifts and integrating image priors.
Area of Science:
- Medical Imaging
- Artificial Intelligence
- Deep Learning
Background:
- Magnetic Resonance Imaging (MRI) acquisition is time-consuming, limiting its clinical utility.
- Existing deep learning acceleration methods require extensive fully-sampled data for supervised training.
- Self-supervised methods face challenges with input distribution shifts and insufficient incorporation of image priors.
Purpose of the Study:
- To develop a novel self-supervised deep unfolding network for accelerated MRI acquisition using only under-sampled datasets.
- To address the input distribution shift issue inherent in current self-supervised learning approaches.
- To enhance MRI reconstruction performance by effectively integrating imaging physics and image priors.
Main Methods:
- Proposed a re-visible dual-domain self-supervised deep unfolding network.
- Incorporated a re-visible dual-domain loss to utilize all under-sampled k-space data, mitigating training-inference distribution shifts.
- Developed a Deep Unfolding Network based on Chambolle and Pock Proximal Point Algorithm (DUN-CP-PPA) with a Spatial-Frequency Feature Extraction (SFFE) block for end-to-end reconstruction.
Main Results:
- The proposed method effectively mitigates the input distribution shift by utilizing all available under-sampled k-space data.
- The integration of imaging physics and comprehensive image priors through the SFFE block significantly enhances reconstruction performance.
- Experimental results on single-coil and multi-coil datasets demonstrate superior reconstruction quality and generalization capability compared to state-of-the-art methods.
Conclusions:
- The novel self-supervised deep unfolding network offers a promising solution for accelerated MRI acquisition without requiring fully-sampled data.
- The re-visible dual-domain approach and DUN-CP-PPA architecture effectively address limitations of previous self-supervised methods.
- The method achieves state-of-the-art performance, paving the way for more efficient and widely applicable MRI techniques.

