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Technology and Dementia Preconference.

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Fastball, an EEG method, accurately detects memory impairment in Mild Cognitive Impairment (MCI). This passive, objective biomarker shows promise for early dementia assessment.

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Area of Science:

  • Neuroscience
  • Biomarkers
  • Cognitive Function

Background:

  • Emerging dementia pharmacotherapies and biomarkers necessitate accurate cognitive function measures.
  • Fastball, an EEG method, objectively measures recognition memory passively.
  • Previous studies showed Fastball's sensitivity to Alzheimer's disease cognitive dysfunction.

Purpose of the Study:

  • To present evidence of Fastball's sensitivity to amnestic dysfunction in Mild Cognitive Impairment (MCI).
  • To validate Fastball as a biomarker for early-stage dementia.

Main Methods:

  • 53 MCI patients and 54 controls underwent a 3-minute Fastball EEG task.
  • Participants completed memory, attention, and general cognitive assessments.
  • Test-retest reliability and longitudinal sensitivity were assessed over one year.

Main Results:

  • Amnestic MCI patients exhibited significantly reduced Fastball responses compared to non-amnestic MCI patients and controls.
  • Fastball EEG responses selectively predicted recognition memory, not attention.
  • Fastball demonstrated moderate to good test-retest reliability in controls.

Conclusions:

  • Fastball is validated as a viable method for assessing recognition memory in MCI.
  • The method is selectively predictive of memory dysfunction.
  • Fastball is a passive, non-invasive, and scalable EEG biomarker for advancing cognitive assessment in MCI.