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Catarina Tristão-Pereira1,2, Ana Y Baena3, Natalia Londono4

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Summary
This summary is machine-generated.

Mild behavioral impairment (MBI) is more common in individuals with genetic risk for Alzheimer's disease (AD). MBI is linked to reduced brain metabolism, suggesting it may precede cognitive decline in AD.

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Area of Science:

  • Neuroscience
  • Neurology
  • Geriatrics

Background:

  • Neuropsychiatric symptoms are common in dementia, often appearing early.
  • Mild behavioral impairment (MBI) in non-demented individuals involves motivation, emotion, and perception changes.
  • The link between MBI and neurodegeneration is inconsistent, prompting further investigation.

Purpose of the Study:

  • To investigate the relationship between MBI and cerebral glucose metabolism in autosomal-dominant Alzheimer's disease (AD).
  • To assess MBI as a potential early indicator of neurodegeneration and disease progression.

Main Methods:

  • Utilized data from the Colombia-Boston Biomarkers Study, comparing Presenilin-1 E280A mutation carriers and non-carriers.
  • Assessed MBI using the MBI-Checklist (MBI-C) and measured cerebral glucose metabolism via 18F-fluorodeoxyglucose (FDG) PET in the precuneus.
  • Employed mediation analysis with amyloid and tau PET imaging to explore the role of AD pathology in the MBI-FDG uptake association.

Main Results:

  • MBI positivity was significantly higher in mutation carriers (68%) versus non-carriers (35%).
  • Participants with MBI showed reduced precuneus FDG uptake, particularly among carriers, indicating hypometabolism in an early AD-related region.
  • AD pathology partially mediated the association between MBI and reduced brain metabolism (70%).

Conclusions:

  • MBI is associated with hypometabolism in an early AD-related region among mutation carriers, partially mediated by AD pathology.
  • These findings suggest MBI may be a risk factor for AD progression, potentially preceding neurodegeneration and cognitive impairment.
  • Further research with larger sample sizes is needed to validate MBI as a marker for identifying individuals at high risk for AD and for prevention strategies.