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The Latin American Spanish PACC5 (LAS-PACC5): Advancing Cognitive Assessment in Latinos
Nadeshka Ramirez-Perez1,2, Isabel Solis1, Lusiana Martinez1,2
1Department of Psychiatry Massachusetts General Hospital, Harvard Medical School Boston Massachusetts USA.
Introduction:
To address the need for validated Spanish-language cognitive assessments in Latino populations at risk for Alzheimer's disease (AD), we evaluated the psychometric performance of a Latin American Spanish adaptation of the Preclinical Alzheimer's Cognitive Composite-5 (LAS-PACC5).
Methods:
A total of 121 Spanish-speaking older adults from the Boston Latino Aging Study (BLAST; Mean age = 64.98 ± 6.98 years; 69% female) were included. The LAS-PACC5 replaced literacy-dependent tasks with culturally and linguistically appropriate measures. Convergent validity was examined using measures validated in diverse Spanish-speaking populations.
Results:
LAS-PACC5 showed moderate associations with naming ability, episodic memory, and global cognition (all p's < 0.001) and differentiated cognitively unimpaired (n = 98) from impaired participants (n = 23; p = 0.005). Results were consistent across alternative cognitive classification approaches.
Discussion:
The LAS-PACC5 demonstrated convergent and discriminative validity, supporting its utility for early cognitive assessment in Spanish-speaking older adults and for improving Latino representation in AD Research.
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