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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
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Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
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Related Experiment Video

Updated: Jan 8, 2026

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
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Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

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Alzheimer's Imaging Consortium.

Joshua L Gills1, Hubert Leo2, Omonigho M Bubu1

  • 1NYU Grossman School of Medicine, New York, NY, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 23, 2025
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Summary
This summary is machine-generated.

Alzheimer's disease (AD) biomarkers like amyloid-beta and tau show strong correlations on the Alamar platform. Associated proteins involve inflammation, connective tissue, and vascular function.

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Area of Science:

  • Neuroscience
  • Biochemistry
  • Biomarker Discovery

Background:

  • Plasma biomarkers such as amyloid-beta (Aβ) and phosphorylated tau (p-tau) are crucial for Alzheimer's disease (AD) risk assessment.
  • Emerging Nucleic Acid-Linked Immuno-Sandwich Assay (NULISA) platforms offer precise detection of low-abundance proteins.

Purpose of the Study:

  • To examine the internal correlations between AD-related biomarkers (amyloid, tau, neurodegeneration, inflammation [ATN & I]) and a broader panel of 126 CNS proteins using the Alamar NULISA platform.
  • To evaluate the associations between specific ATN & I biomarkers and other CNS proteins.

Main Methods:

  • Cross-sectional analysis of plasma samples from 116 ARIC participants.
  • Quantification of 126 CNS analytes using the ALAMAR NULISA platform.
  • Multiple linear regression and Spearman's Rho correlations were used to assess biomarker associations, adjusting for covariates.

Main Results:

  • Amyloid-beta (Aβ) proteinopathy markers showed moderate to strong correlations (ρ = .52-.88) and mild to moderate correlations with phosphorylated tau (p-tau) markers (ρ = .20-.68).
  • 38 plasma proteins associated with neurofilament light (NfL), 37 with Aβ-42/Aβ-40, and 35 with Tau were identified among the 126 analytes.
  • Top associated proteins included IL-33, MAPT, VEGFD, TAFA-5, FOLR1, and GDB/1.

Conclusions:

  • AD-specific proteins exhibit moderate to strong inter-correlations on the Alamar platform.
  • Proteins associated with inflammation, connective tissue integrity, and vascular function were significantly linked to ATN & I biomarkers.
  • Longitudinal studies across the AD continuum are recommended for further investigation.