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Ting Wen W Goh1, Keven Ang2, Serena Low2

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Cognitive function in visuospatial-construction and immediate memory is linked to better quality of life (QOL) in type 2 diabetes patients. These findings may guide interventions to enhance QOL by targeting specific cognitive domains.

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Area of Science:

  • Neuroscience
  • Endocrinology
  • Psychology

Background:

  • Type 2 diabetes (T2D) is associated with cognitive impairment and reduced quality of life (QOL).
  • The specific cognitive domains impacting QOL in T2D patients remain unclear.

Purpose of the Study:

  • To investigate the association between specific cognitive domains and QOL in patients with T2D.

Main Methods:

  • A cross-sectional study involving 327 T2D patients from the SMART2D cohort.
  • Cognitive function was assessed using the Repeatable Battery for Assessment of Neuropsychological Status (RBANS), evaluating immediate memory, delayed memory, visuospatial-construction, language, and attention.
  • Quality of life was measured using the Euroqol EQ-5D, including the visual analogue scale (VAS) and domains for mobility, self-care, usual activities, pain/discomfort, and depression/anxiety.

Main Results:

  • Visuospatial-construction ability correlated with a higher EQ-5D index score and reduced likelihood of problems in mobility, usual activities, and self-care.
  • Immediate memory function was associated with a higher VAS score.
  • Adjusted analyses accounted for demographics, clinical factors, and medications.

Conclusions:

  • Enhanced visuospatial-construction and immediate memory function are linked to improved QOL in T2D patients.
  • These results suggest potential therapeutic targets for interventions aimed at improving QOL in this population.