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Alzheimer's Imaging Consortium.

Mary K Kramer1, Nicholas J Pyontek1, Nicholas A Rizzi1

  • 1University of Delaware, Newark, DE, USA.

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Summary
This summary is machine-generated.

Magnetic Resonance Elastography (MRE) reveals reduced brain stiffness correlating with Alzheimer's Disease (AD) biomarkers in asymptomatic individuals. This suggests MRE can detect early AD-related brain changes using accessible blood tests.

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Area of Science:

  • Neuroimaging
  • Biomarker Discovery
  • Alzheimer's Disease Research

Background:

  • Alzheimer's Disease (AD) pathology, including amyloid and tau accumulation, can be present years before clinical symptoms.
  • The asymptomatic stage offers a critical window for therapeutic intervention.
  • Magnetic Resonance Elastography (MRE) quantifies brain tissue stiffness, detecting early microstructural changes.

Purpose of the Study:

  • To investigate the relationship between brain mechanical properties and plasma-based Alzheimer's Disease (AD) biomarkers.
  • To assess the potential of MRE in detecting early AD-related changes in asymptomatic individuals.

Main Methods:

  • Recruited 12 adults (46-81 years) from the Delaware Longitudinal Study for Alzheimer's Prevention.
  • Quantified plasma amyloid-beta (Aβ) and phosphorylated tau (pTau-181, pTau-217) using Simoa assays.
  • Measured hippocampal and entorhinal cortex (ERC) stiffness using MRE.

Main Results:

  • Hippocampal stiffness inversely correlated with plasma pTau-181 and Aβ40.
  • ERC stiffness showed similar inverse correlation with pTau-181 and near-significant correlation with pTau-217.
  • Individuals with lower AD biomarker concentrations exhibited higher stiffness in the hippocampus and ERC.

Conclusions:

  • This study is the first to link brain mechanical properties with plasma AD biomarkers.
  • Reduced stiffness in the hippocampus and ERC suggests microstructural disruption due to protein accumulation.
  • MRE measures show sensitivity to protein aggregate impact, supporting early AD detection via blood biomarkers.