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Public Health.

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Summary
This summary is machine-generated.

Epigenetic age acceleration measures predict survival to age 90 in women, but do not distinguish between those with or without preserved cognition. Further development is needed for cognitive status prediction.

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Area of Science:

  • Epigenetics
  • Gerontology
  • Cognitive Science

Background:

  • Epigenetic age-acceleration estimators (EAA) predict mortality but were not trained on longevity or preserved cognition.
  • The ability of EAA measures to predict long survival with intact cognition remains largely unknown.

Purpose of the Study:

  • To investigate whether EAA measures predict survival to age 90 with preserved cognition.
  • To compare the predictive power of EAA measures for survival with versus without cognitive impairment.

Main Methods:

  • Analysis of 5293 women from the WHIMS cohort, born before February 28, 1934.
  • Examined 14 EAA estimators in relation to survival to age 90 with preserved cognition, without preserved cognition, or death before age 90.
  • Used multinomial logistic regression, adjusting for multiple covariates including age, education, race, and health factors.

Main Results:

  • All accelerated age estimators were associated with survival to age 90 with cognitive impairment.
  • Associations were in the same direction and similar magnitude for survival to age 90 without cognitive impairment.
  • Principle component (PC) versions of estimators showed slightly stronger associations for both longevity outcomes.

Conclusions:

  • EAA measures consistently predict survival to age 90 in older women.
  • EAA measures do not differentially predict survival with or without intact cognition.
  • Findings support developing EAA measures specifically trained on preserved cognitive status in advanced age.