Related Experiment Video
Updated: Jan 8, 2026
10:57
Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
Published on: August 22, 2012
24.2K
Public Health.
Lucy Y Eum1, Pilar Robinson Gonzalez1, Sanja Stanojevic1
1Dalhousie University, Halifax, NS, Canada.
Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 23, 2025
Summary
Antidepressant use is linked to higher Alzheimer's Disease (AD) risk, particularly in females. This association was not modified by frailty or neuropathology, highlighting potential sex-specific risk factors.
Area of Science:
- Neurology
- Gerontology
- Pharmacology
Background:
- Depression is a known modifiable risk factor for dementia.
- The long-term impact of antidepressant use on Alzheimer's Disease (AD) development is not well understood.
- Investigating potential links between antidepressants and AD is crucial for dementia prevention strategies.
Purpose of the Study:
- To examine the association between antidepressant exposure and the clinical diagnosis of Alzheimer's Disease (AD).
- To determine if binary sex, frailty, or neuropathology modifies the relationship between antidepressant use and AD.
- To provide insights into modifiable risk factors for dementia.
Main Methods:
- Retrospective analysis of secondary data from a multi-site cohort study.
- Inclusion of 930 participants aged 55+ with normal cognition.
- Assessment of frailty using a 30-item frailty index (FI) and frailty phenotype, and neuropathology using a 10-item neuropathology index (NPI) based on autopsy findings. Logistic regression was employed for statistical analysis.
Main Results:
- Antidepressant exposure was significantly associated with increased odds of AD (OR 2.51).
- This association remained significant after adjusting for age, sex, frailty, and NPI (OR 3.11).
- Stratification by sex revealed a significant association in females (OR 3.93) but not in males (OR 1.86) after adjustments. The association was not significantly modified by sex, frailty, or NPI.
Conclusions:
- Antidepressant use is significantly associated with increased odds of developing Alzheimer's Disease (AD).
- The association between antidepressant use and AD is more pronounced in females than in males.
- The study did not find significant modifications of the antidepressant-AD association by sex, frailty, or neuropathology index.
More Related Videos
09:33Visualizing Field Data Collection Procedures of Exposure and Biomarker Assessments for the Household Air Pollution Intervention Network Trial in India
Published on: December 23, 2022
2.6K
07:20Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
Published on: January 28, 2014
37.1K
Related Concept Videos
01:30Primary Healthcare Services
1.9K
Primary care promotes wellness and prevents disease. This care includes health promotion, education, protection (such as immunizations), early disease screening, and environmental considerations. Settings providing this type of healthcare include physician offices, public health clinics, school nursing, and community health nursing.
In 1978, international leaders convened in Alma-Ata, Kazakhstan, for what would be a pivotal event in global health. The Alma-Ata Declaration was the first to call...
In 1978, international leaders convened in Alma-Ata, Kazakhstan, for what would be a pivotal event in global health. The Alma-Ata Declaration was the first to call...
1.9K
01:26Levels of Health Promotion and Illness Prevention
14.1K
Health promotion allows a person to control the determinants of health, resulting in an improved health status. It enhances the quality of life and reduces premature deaths. Health promotion and illness prevention programs help people make beneficial choices to reduce the risk of disease and disabilities. There are three health promotion and illness prevention levels: primary, secondary, and tertiary prevention.
In primary prevention, actions taken before disease onset prevent the disease from...
In primary prevention, actions taken before disease onset prevent the disease from...
14.1K
01:30Preventive Healthcare Services
1.8K
Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
1.8K
01:26Principles of Disease Surveillance
439
Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
439
01:17Healthcare Agencies II
1000
There are various healthcare agencies in the United States—some of which are managed by religious institutions and others by different government branches.
Parish nursing is a growing specialty nursing profession that focuses on holistic healthcare, health promotion, and illness prevention. It blends professional nursing practice with a health ministry, focusing on health and healing within the context of a Christian community. Parish nurses serve as health educators, referral sources,...
Parish nursing is a growing specialty nursing profession that focuses on holistic healthcare, health promotion, and illness prevention. It blends professional nursing practice with a health ministry, focusing on health and healing within the context of a Christian community. Parish nurses serve as health educators, referral sources,...
1000
01:26Methods Of Healthcare Delivery System
3.9K
At the different levels of the healthcare system, we see varying methods of healthcare used. These methods include managed care systems, case management, and primary healthcare.
Managed Care System:
The managed care system is designed to control the cost while maintaining the quality of care. The patient's care from admission to discharge is planned by the primary care provider or the case manager, also known as the gatekeeper. In a managed care system, the number of care providers is...
Managed Care System:
The managed care system is designed to control the cost while maintaining the quality of care. The patient's care from admission to discharge is planned by the primary care provider or the case manager, also known as the gatekeeper. In a managed care system, the number of care providers is...
3.9K