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Summary
This summary is machine-generated.

An abbreviated digital Trail Making Test-Part B effectively screens for mild cognitive impairment (MCI) by measuring time spent in targets, correlating with attention and memory deficits. This digital tool aids early Alzheimer's disease detection.

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Area of Science:

  • Neurology
  • Cognitive Science
  • Digital Health

Background:

  • Emerging monoclonal antibody treatments for Alzheimer's disease (AD) necessitate early screening for mild cognitive impairment (MCI).
  • Novel digital Trail Making Test-Part B (dTMT-B) metrics show promise in differentiating MCI from normal cognition (NC).

Purpose of the Study:

  • To develop and validate an abbreviated dTMT-B for screening MCI versus NC.
  • To explore relationships between the abbreviated dTMT-B and traditional neuropsychological tests.

Main Methods:

  • An abbreviated dTMT-B (targets 1-F) was administered to 58 memory clinic patients (MCI vs. NC).
  • Process metrics included hit duration, distance, and pen stroke velocity.
  • Statistical analyses (ANOVA, partial correlations) controlled for age, education, and sex.

Main Results:

  • MCI patients exhibited longer hit duration compared to NC patients (p < 0.004).
  • Longer hit duration correlated with poorer performance in attention (r=-0.724), working memory (r=-0.520), and episodic memory (r=-0.411).
  • No significant differences were found for distance or velocity.

Conclusions:

  • An abbreviated digital TMT-B provides novel process metrics for cognitive assessment.
  • This abbreviated digital test is a versatile tool for screening emergent cognitive impairment, aiding early AD diagnosis.