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Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
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Public Health.

Maude Wagner1, Puja Agarwal1, Klodian Dhana2

  • 1Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.

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|December 23, 2025
PubMed
Summary
This summary is machine-generated.

Adopting a healthy lifestyle, indicated by lower LIfestyle for BRAin health (LIBRA) scores, is linked to better cognitive resilience. Cognitively stimulating activities show the strongest association with preserved cognition despite brain pathology.

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Area of Science:

  • Neurology
  • Gerontology
  • Public Health

Background:

  • Cognitive resilience (CR) is the ability to maintain cognitive function despite neuropathology.
  • The influence of modifiable lifestyle and health factors on CR is not well understood.

Purpose of the Study:

  • To investigate the association between the LIfestyle for BRAin health (LIBRA) index and cognitive resilience.
  • To identify specific lifestyle components that may promote cognitive resilience in older adults.

Main Methods:

  • 585 decedents from the Rush Memory and Aging Project were analyzed.
  • Neuropathological examination and cognitive evaluations were performed.
  • Linear mixed-effects models assessed CR (CRLevels and CRslope) and linear regression examined LIBRA index associations.

Main Results:

  • Lower LIBRA scores were linearly associated with higher CRLevels and CRslope.
  • Cognitively stimulating activities demonstrated the strongest association with both CR measures.
  • Lower LIBRA scores were associated with higher CRLevels in participants with no, single CVD, or single neurodegenerative pathology.

Conclusions:

  • Lifestyle modification and health management programs can promote cognitive resilience in older adults.
  • Interventions targeting lifestyle factors may help preserve cognitive health by enhancing resilience to neuropathology.