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Related Experiment Video

Updated: Jan 8, 2026

Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
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Public Health.

Yun Jin Chen1,2, Arlen Gaba2,3, Peng Li4,5

  • 1Queen's University School of Medicine, Kingston, ON, Canada.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 23, 2025
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Summary

Higher Alzheimer's disease polygenic risk scores (AD-PRS) are linked to increased postoperative delirium (POD) risk in patients without dementia. This association holds true regardless of sleep burden, sex, or age.

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Area of Science:

  • Neuroscience
  • Genetics
  • Gerontology

Background:

  • Postoperative delirium (POD) affects up to one-third of surgical patients, increasing morbidity and mortality.
  • The genetic risk factor APOE-ε4 for Alzheimer's disease (AD) has an inconsistent association with POD.
  • Investigating polygenic risk scores for AD (AD-PRS) may clarify POD susceptibility.

Purpose of the Study:

  • To determine if a higher AD-PRS predicts an increased risk of POD in patients without pre-existing dementia.
  • To examine how sleep burden modifies the relationship between AD-PRS and POD risk.

Main Methods:

  • Prospective cohort study of 500,000 UK Biobank participants over a 12-year median follow-up.
  • POD cases identified via ICD-10 coding within three days of surgery; participants with pre-existing dementia excluded.
  • Cox proportional hazard models used to assess AD-PRS association with POD risk, adjusting for covariates and sleep burden.

Main Results:

  • Higher AD-PRS quartiles showed a stepwise increase in POD risk compared to the lowest quartile.
  • Individuals in the highest AD-PRS quartiles (Q3 and Q4) had significantly higher POD risk (HR 1.23-1.35).
  • AD-PRS remained a consistent predictor of POD risk across different sleep burden levels, sexes, and age groups.

Conclusions:

  • Elevated AD-PRS is independently associated with increased POD risk in adults without dementia.
  • The predictive power of AD-PRS for POD is consistent across sleep burden, sex, and age.
  • Findings suggest polygenic Alzheimer's risk contributes to surgical delirium susceptibility beyond APOE-ε4.