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Basic Science and Pathogenesis.

Titikorn Chunchai1,2, Hiranya Pintana1,2, Patcharapong Pantiya1,2

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Lactobacillus reuteri KUB-AC5 probiotic administration improved cognitive function in obese rats by reducing metabolic issues and oxidative stress. This highlights its potential for treating metabolic and neurodegenerative disorders.

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Area of Science:

  • Neuroscience
  • Microbiology
  • Metabolic Science

Background:

  • Chronic high-fat diet (HFD) consumption leads to gut dysbiosis, endotoxemia, and cognitive impairment.
  • Probiotics like Lactobacillus paracasei HII01 have shown benefits for metabolic and cognitive health in obese rats.
  • The specific effects of Lactobacillus reuteri KUB-AC5 on these parameters in obese, insulin-resistant rats remain uninvestigated.

Purpose of the Study:

  • To investigate the effects of Lactobacillus reuteri KUB-AC5 on cognitive function, metabolic disturbances, and brain mitochondrial function in obese, insulin-resistant rats.
  • To determine if L. reuteri KUB-AC5 can mitigate HFD-induced negative health outcomes.

Main Methods:

  • Male Wistar rats were fed either a normal diet (ND) or HFD for 24 weeks.
  • From week 13, subgroups received vehicle or L. reuteri KUB-AC5 (10^8 CFU/day) for 12 weeks.
  • Cognitive function, metabolic markers, and brain mitochondrial function were assessed.

Main Results:

  • HFD increased body weight, visceral fat, cholesterol, insulin, HOMA-IR, and serum MDA.
  • L. reuteri KUB-AC5 treatment significantly reduced body weight, insulin, serum MDA, and HOMA-IR in HFD rats.
  • Probiotic treatment improved brain mitochondrial function, increased dendritic spine density, and attenuated cognitive decline in HFD rats.

Conclusions:

  • L. reuteri KUB-AC5 administration mitigates cognitive decline in obese insulin-resistant rats.
  • The probiotic alleviates metabolic disturbances, reduces oxidative stress, and enhances brain mitochondrial function and neuronal plasticity.
  • L. reuteri KUB-AC5 shows potential as a therapeutic agent for metabolic and neurodegenerative disorders.