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Updated: Jan 8, 2026
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Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
Published on: August 22, 2012
24.2K
Public Health
Noha Keshk1, Hussein Khalil1, Richard Holden2,3
1Purdue University, West Lafayette, IN, USA.
Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 23, 2025
Summary
Angiotensin II-stimulating antihypertensives users showed better cognitive function than non-users and those on Ang II-inhibiting drugs. Mixed users performed worse, except in memory, highlighting potential benefits of specific antihypertensive pathways for cognitive health.
Area of Science:
- Neuroscience
- Pharmacology
- Gerontology
Background:
- Dementia prevention is crucial in the absence of a cure.
- Antihypertensives targeting Angiotensin II (Ang II) pathways may offer neuroprotection.
- Comparing Ang II-stimulating vs. Ang II-inhibiting drugs for cognitive health is warranted.
Purpose of the Study:
- To evaluate the impact of Ang II-stimulating antihypertensives versus Ang II-inhibiting antihypertensives on cognitive function.
- To compare cognitive performance between different classes of antihypertensive users and non-users.
Main Methods:
- Retrospective analysis of 705 participants from the BrainSafe clinical trial.
- Cognitive data linked with two-year pre-enrollment electronic medical records.
- Participants categorized into control, Ang II-stimulating, Ang II-inhibiting, and mixed antihypertensive user groups.
Main Results:
- Ang II-stimulating antihypertensive users demonstrated higher cognitive scores across memory, language, executive functioning, processing speed, and global cognition compared to controls.
- Ang II-inhibiting antihypertensive users showed lower cognitive scores in most domains compared to controls.
- Mixed users exhibited poorer performance in most cognitive domains, with the exception of memory.
Conclusions:
- Ang II-stimulating antihypertensives are associated with enhanced cognitive performance.
- Ang II-inhibiting antihypertensives may be linked to diminished cognitive function.
- Medication choice within antihypertensive classes may differentially impact cognitive health and dementia risk.
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