Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Skin cancer and immunosuppression.

B K Walder, M R Robertson, D Jeremy

    Lancet (London, England)
    |December 11, 1971
    PubMed
    Summary
    This summary is machine-generated.

    Kidney transplant recipients on immunosuppressive drugs face a higher risk of developing skin cancers, including squamous-cell carcinoma. These cancers can appear years after transplantation and may recur rapidly.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Widespread plaque psoriasis responsive to mycophenolate mofetil.

    The Australasian journal of dermatology·1999
    Same author

    Association of acute leukaemia with chlorambucil after renal transplantation.

    Lancet (London, England)·1994
    Same author

    Dermal myiasis in an Australian traveller.

    The Australasian journal of dermatology·1993
    Same author

    Right vocal cord paralysis after internal jugular vein cannulation.

    The Journal of laryngology and otology·1989
    Same author

    Idiopathic retroperitoneal fibrosis presenting with back pain.

    The Journal of rheumatology·1988
    Same author

    Folic acid lowers elevated plasma homocysteine in chronic renal insufficiency: possible implications for prevention of vascular disease.

    Metabolism: clinical and experimental·1988

    Area of Science:

    • Nephrology
    • Dermatology
    • Oncology

    Background:

    • Immunosuppressive therapy is crucial for kidney transplant recipients to prevent organ rejection.
    • Long-term immunosuppression is associated with an increased risk of various cancers, including lymphoreticular malignancies.
    • The specific impact of immunosuppression on non-lymphoid skin cancers in kidney transplant patients requires further elucidation.

    Purpose of the Study:

    • To investigate the incidence and characteristics of malignant skin tumors in kidney-allograft recipients.
    • To assess the relationship between immunosuppressive treatment and the development of specific skin cancers.
    • To understand the progression and recurrence patterns of skin cancers under immunosuppression.

    Main Methods:

    • Retrospective analysis of 51 kidney-allograft recipients.

    Related Experiment Videos

  • Monitoring for the development of skin tumors post-transplantation (4-45 months).
  • Documentation of tumor type, number, and recurrence.

    • Main Results:

    • 7 out of 51 (14%) recipients developed 19 malignant skin tumors.
    • Squamous-cell carcinoma was a prominent diagnosis, with accelerated progression from hyperkeratosis observed.
    • Increased frequency and early recurrence of keratoacanthoma were noted.
    • Multiple skin cancers occurred in some patients.

    Conclusions:

    • Kidney transplant recipients on immunosuppression have a significantly elevated risk of developing malignant skin tumors, particularly squamous-cell carcinoma.
    • Immunosuppressive regimens may promote the rapid evolution and recurrence of skin cancers.
    • Close dermatological surveillance is essential for early detection and management of skin malignancies in this patient population.