Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stroke: Introduction and Types01:29

Stroke: Introduction and Types

75
A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...
75
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

57
Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
57
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

74
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
74
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

41
A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
41
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

57
A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
57
Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

35
A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...
35

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Differentiating effective salvage from ineffective delayed compensation in anterior circulation stroke: a dynamic quantitative collateral index.

Frontiers in medicine·2026
Same author

MRI-based radiomics-deep learning model for preoperative pathogen prediction in perianal abscesses.

Frontiers in medicine·2026
Same author

Multimodal Fusion Network with Information Bottleneck Mamba and Intervention Enhancement for Retinal Disease Diagnosis.

IEEE journal of biomedical and health informatics·2026
Same author

Multimodal Magnetic Resonance Imaging in Diabetic Kidney Disease: From Pathophysiological Insights to Clinical Applications.

Diagnostics (Basel, Switzerland)·2026
Same author

Advanced High-Entropy Biomaterials (HEBs).

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Evaluation of cartilaginous endplate degeneration with histogram features of multiple parameters in UTE MRI.

BMC medical imaging·2026
Same journal

Cationic nanotrap curbs UVB-induced cutaneous photodamage via exosomal cfNA capture.

Biomaterials·2026
Same journal

A protein-initiated polymerization cascade enables a self-eliminating powder tissue adhesive for diabetic ulcer repair.

Biomaterials·2026
Same journal

Oral colon-targeted micro-nano formulation engineered in microfluid for synergistic therapy of inflammatory bowel disease.

Biomaterials·2026
Same journal

Manganese@Gold cluster-coordinated covalent organic frameworks-based artificial metalloenzymes with cascade biocatalysis and amplified systemic stimulation to combat malignant tumor metastasis.

Biomaterials·2026
Same journal

Remodeling TME via feedback-driven photothermal-ferroptosis-immune cascade.

Biomaterials·2026
Same journal

Corrigendum to "Photodynamic therapy produces enhanced efficacy of antitumor immunotherapy by simultaneously inducing intratumoral release of sorafenib" [Biomaterials 2020, 240, 119845].

Biomaterials·2026
See all related articles

Related Experiment Video

Updated: May 6, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

15.4K

Ischemic stroke nanomedicine.

Lan Luo1, Meiqi Chang2, Ying Wang3

  • 1University of Shanghai for Science and Technology, Shanghai, 200093, PR China.

Biomaterials
|December 23, 2025
PubMed
Summary
This summary is machine-generated.

Nanomedicine offers advanced solutions for early stroke diagnosis and treatment, overcoming current limitations. This review highlights nanotechnology

Keywords:
Diagnostic imagingIschemic strokeNanodrug deliveryNanomedicineNanoprobes

More Related Videos

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia
14:53

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia

Published on: June 26, 2020

10.9K
Author Spotlight: Establishing a Reliable Distal MCA Occlusion Model in Mice for Stroke Research
07:34

Author Spotlight: Establishing a Reliable Distal MCA Occlusion Model in Mice for Stroke Research

Published on: December 15, 2023

3.2K

Related Experiment Videos

Last Updated: May 6, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

15.4K
Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia
14:53

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia

Published on: June 26, 2020

10.9K
Author Spotlight: Establishing a Reliable Distal MCA Occlusion Model in Mice for Stroke Research
07:34

Author Spotlight: Establishing a Reliable Distal MCA Occlusion Model in Mice for Stroke Research

Published on: December 15, 2023

3.2K

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Neurology

Background:

  • Stroke incidence is rising globally due to aging populations and lifestyle changes.
  • Current stroke diagnosis and treatment methods have significant limitations.
  • Nanomedicine presents a promising approach to address these challenges.

Purpose of the Study:

  • To review the role of nanomedicine in advancing early diagnosis and treatment of ischemic stroke.
  • To discuss nanomaterial properties, design strategies, and applications in stroke management.
  • To explore challenges and future directions for clinical translation of nanomedicine in stroke theranostics.

Main Methods:

  • Literature review focusing on nanomedicine applications in ischemic stroke.
  • Analysis of nanomaterial compositions and surface designs for diagnostic and therapeutic purposes.
  • Examination of nanoplatforms for imaging, drug delivery, and multifunctional theranostics.

Main Results:

  • Nanomaterials serve as effective contrast agents for enhanced stroke imaging.
  • Nanocarriers facilitate targeted drug delivery for improved therapeutic efficacy.
  • Multifunctional nanosystems offer integrated diagnostic and therapeutic capabilities for stroke management.

Conclusions:

  • Nanomedicine holds significant potential to revolutionize ischemic stroke theranostics.
  • Addressing challenges in clinical translation is crucial for adopting nanotechnology in stroke care.
  • Future research should focus on optimizing nanomedicine for improved patient outcomes and clinical adoption.