The SPECTACLE Study: A Multicenter, Prospective, Single-Arm Trial Evaluating Quantitative Blood Flow Assessment Using
Atsushi Hamabe1, Mamoru Uemura1, Yusuke Suwa2
1Department of Gastroenterological Surgery, The University of Osaka, Osaka, Japan.
Asian Journal of Endoscopic Surgery
|December 23, 2025
Summary
This study evaluates quantitative indocyanine green (ICG) fluorescence imaging with SPY-QP software to reduce anastomotic leakage (AL) after rectal cancer surgery. Objective perfusion assessment may improve patient outcomes and surgical strategies.
Area of Science:
- Colorectal Surgery
- Surgical Oncology
- Medical Imaging
Background:
- Anastomotic leakage (AL) is a significant complication following rectal cancer surgery.
- Current indocyanine green (ICG) fluorescence imaging for bowel perfusion assessment relies on subjective interpretation.
- SPY-QP software offers quantitative evaluation of ICG fluorescence for improved accuracy.
Purpose of the Study:
- To evaluate if SPY-QP quantitative blood flow assessment can reduce AL rates after rectal cancer surgery.
- To compare the efficacy of objective perfusion assessment against historical controls.
- To explore the potential for broader adoption of quantitative imaging in colorectal procedures.
Main Methods:
- The SPECTACLE study is a multicenter, prospective, single-arm trial.
- Enrollment of 400 patients undergoing laparoscopic or robotic rectal cancer resection.
- Primary endpoint: incidence of AL (Grades A-C) within 30 days postoperatively.
Main Results:
- This section is not available in the provided abstract.
Conclusions:
- This trial aims to provide robust evidence on the effectiveness of objective perfusion assessment using SPY-QP.
- Demonstrating reduced AL rates could lead to wider implementation of quantitative imaging in surgery.
