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This study found no cognitive differences in healthy women based on APOE4 gene status. Further research with APOE4 homozygotes is needed to understand Alzheimer

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Area of Science:

  • Neuroscience
  • Genetics
  • Cognitive Science

Background:

  • Late-onset Alzheimer's Disease (AD) disproportionately affects women, with over 65% of cases occurring in females.
  • The apolipoprotein E e4 allele (APOE-e4) is a known AD risk factor, and women may be more susceptible to its negative effects.

Purpose of the Study:

  • To investigate the impact of APOE-e4 carrier status on cognitive performance in healthy, working-age women.
  • To explore potential sex-based differences in AD risk factors.

Main Methods:

  • 114 healthy female volunteers (aged 30-65) were recruited.
  • Participants underwent comprehensive assessments including demographics, vascular risk factors, mood, neuropsychological testing, and the Cognitive Reserve Index Questionnaire (CRIq).
  • Statistical analysis was performed using SPSS20, comparing APOE4 heterozygotes to non-carriers.

Main Results:

  • The study included 27 APOE4 heterozygotes, 2 homozygotes, and 85 non-carriers.
  • No significant differences in cognitive performance were found across various domains (attention, memory, executive functions, etc.) between APOE4 heterozygotes and non-carriers.
  • Average age was 48.15±8.41 years, with an average of 19.02 years of education.

Conclusions:

  • APOE4 carrier status did not correlate with cognitive performance differences in this cohort of healthy, working-age females.
  • Further research, particularly including individuals with APOE4 homozygous status, is necessary to fully understand the relationship between APOE polymorphism and cognitive decline.