Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Infection01:20

Infection

11.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.6K
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

524
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
524
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

676
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
676
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

2.5K
The pathophysiology of pneumonia involves the following steps:
2.5K
Stages of Infection01:26

Stages of Infection

64.7K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
64.7K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeting Sensory Neuropathies Through Neurotrophin-Based Approaches.

Cellular and molecular neurobiology·2026
Same author

EEG-motor correlation as early Alzheimer's disease index in herpes simplex virus type-1-infected mice.

Brain communications·2026
Same author

Memantine prevents acute stress-induced memory deficits by reversing sex-dependent pathophysiological glutamatergic alterations in the dorsal hippocampus.

British journal of pharmacology·2026
Same author

Neuroinflammatory responses and synaptic impairment in a Herpes simplex virus type 1 model of sporadic Alzheimer's disease.

Neural regeneration research·2026
Same author

Intranasal administration of neural stem cell-derived extracellular vesicles prevents cognitive decline in both male and female 3×Tg-AD mice by dampening neuroinflammation and epigenetically regulating amyloid β metabolism.

Alzheimer's research & therapy·2026
Same author

AAV.PHP.eB-based strategies for precise modulation of α7 nicotinic acetylcholine receptor in neurons and astrocytes in the adult mouse brain.

Scientific reports·2026

Related Experiment Video

Updated: Jan 8, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K

Basic Science and Pathogenesis.

Claudio Grassi1,2, Francesca Natale2,3, Matteo Spinelli3,4

  • 1Università Cattolica del Sacro Cuore, Rome, Rome, Italy.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 23, 2025
PubMed
Summary
This summary is machine-generated.

Aberrant S-palmitoylation is linked to Alzheimer's disease (AD) cognitive decline. Inhibiting zDHHC enzymes and S-palmitoylation offers a promising therapeutic strategy for AD.

More Related Videos

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

Related Experiment Videos

Last Updated: Jan 8, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K
A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Biochemistry

Background:

  • Protein post-translational modifications, including S-palmitoylation, are vital for synaptic function.
  • Disruptions in these modifications are implicated in neurodegenerative diseases like Alzheimer's disease (AD).
  • Zinc finger DHHC domain-containing (zDHHC) S-acyltransferases catalyze S-palmitoylation, influencing synaptic plasticity and amyloid-β (Aβ) metabolism.

Purpose of the Study:

  • To investigate the role of zDHHC enzymes and S-palmitoylation in AD pathogenesis.
  • To evaluate the therapeutic potential of modulating S-palmitoylation in AD models.

Main Methods:

  • Analysis of zDHHC expression and S-palmitoylation in AD mouse models and human AD patient hippocampi.
  • In vivo inhibition of zDHHC using 2-bromopalmitate (2-BP) or antisense oligonucleotides.
  • Hippocampal zDHHC silencing via lentiviral vectors and short hairpin RNA.
  • Palmitoyl-proteome analysis to identify zDHHC7 targets.

Main Results:

  • Increased zDHHC7 expression and synaptic protein S-palmitoylation observed in AD models and patients.
  • 2-BP treatment and zDHHC7 silencing improved synaptic plasticity, reduced Aβ deposition, and enhanced cognitive function in AD mice.
  • S-palmitoylation levels inversely correlated with cognitive performance in AD patients.
  • Identification of potential zDHHC7 targets involved in neurodegeneration.

Conclusions:

  • Aberrant S-palmitoylation is a key factor in AD-related synaptic dysfunction and cognitive impairment.
  • Targeting zDHHC enzymes presents a novel therapeutic avenue for mitigating cognitive decline in AD.